许恒

  • 四川大学华西医院生物治疗国家重点实验室研究员,博士生导师
  • 国家自然基金委优秀青年
  • 四川“千人计划”学者
  • 中国药理学协会药物基因组分会常委
  • 中国医药生物技术协会精准医疗分会委员
  • 任国际Faculty1000评价体系Pharmacology & Drug Discovery领域推荐专家(Associate Faculty Member)

学习工作经历

2014至今 四川大学华西医院生物治疗国家重点实验室 研究员
2010-2014 美国St. Jude 儿童研究医院 博士后
2004-2010 中国科学院上海生命科学院 博士
2000-2004 南京大学生命科学院 学士

研究方向

主要研究方向为精准医学领域的医学遗传学和药物基因组学。研究主要以临床—基础—临床的思路,从临床疾病和患者样本入手,对相关的基础生物学实验、生物信息学分析、生物统计学分析,以及基础医学(如药理学)进行交叉学科转化研究。 在基因组,表观遗传和肠道微生物等水平寻找肿瘤等疾病的相关变异,为肿瘤等疾病的早期防治,相关靶向药物开发和精准用药等提供候选生物标志物和靶点。研究成果已发表在Nature Genetics、Journal of Clinical Oncology、Journal of National Cancer Institute、Nature Communications等SCI杂志上。课题组还担任十三五重点研发计划“精准医学研究”子课题,自然基金面上项目等多项基础科研项目。

代表文章

  1. Genomic evolution and diverse models of systemic metastases in colorectal cancer.

    Chen H-N*, Shu Y*, Liao F*, Liao X, Zhang H, Qin Y, Wang Z, Luo M, Liu Q, Xue Z, Cao M, Zhang S, Zhang W-H, Hou Q, Xia X, Luo H, Zhang Y, Yang Lie, Hu J-K, Fu X, Liu B, Hu H, Huang C, Peng Y, Cheng W, Dai L, Yang Li, Zhang W, Dong B, Li Y, Wei Y, Xu H#, Zhou Z-G#.
    Gut. 2021; Feb 25

  2. Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer.

    Ding Z*, Li Q*, Zhang R*, Xie L, Shu Y, Gao S, Wang P, Su X, Qin Y, Wang Y, Fang J, Zhu Z, Xia X, Wei G, Wang H, Qian H, Guo X, Gao Z, Wang Y, Wei Y, Xu Q#, Xu H#, Yang L#.
    Signal Transduct Target Ther. 2021; 6(1): 26

  3. Novel recurrent altered genes in Chinese patients with anaplastic thyroid cancer.

    Zhang L*, Ren Z*, Su Z*, Liu Y, Yang T, Cao M, Jiang Y, Tang Y, Chen H, Zhang W, Gong R, Wei T, Peng Y, Liu B, Zhang W, Yang L, Hu Y, Li Z, Zhu J, Xu H#, Shu Y#, Luo H#.
    J Clin Endocrinol Metab.  2021;dgab0146

  4. ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia.

    Xu H*, Zhao X*, Bhojwani D, E S, Goodings C, Zhang H, Seibel NL, Yang W, Li C, Carroll WL, Evans WE, Yang JJ

  5. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics.

    Qian M*, Xu H*, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ.
    Blood. 2019 Feb;133(7):724-729

  6. Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.

    Zhu Y*, Yin D*, Su Y*, Xia X*, Moriyama T, Nishii R, Liao F, Zhang S, Guo X, Hou Q, Ai Y, Zhou X, Sun S, Zhang D, Zhang Y, Lin C, Deng Y, Lu X, Wang Y, Ma Z, Wang H, Liu B, Yang L, Zhang W, Yang JJ, Shu Y#, Gao J#, Xu H#
    Haematologica. 2018;103(7):e293-e295. doi:10.3324/haematol.2018.187658

  7. Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer

    Shu Y*, Zhang W*, Hou Q*, Zhao L*, Zhang S, Zhou J, Song X, Zhang Y, Jiang D, Chen X, Wang P, Xia X, Liao F, Yin D, Chen X, Zhou X, Zhang D, Yin S, Yang K, Liu J, Fu L, Zhang L, Wang Y, Zhang J, An Y, Cheng H, Zheng B, Sun H, Zhao Y, Wang Y, Xie D, Ouyang L, Wang P, Zhang W, Qiu M, Fu X, Dai L, He G, Yang H, Cheng W, Yang L, Liu B, Li W, Dong B, Zhou Z, Wei Y, Peng Y#, Xu H#, Hu J#
    Nat Commun. 2018;9(1):2447. Published 2018 Jun 30.

  8. Presence and diagnostic value of circulating tsncRNA for ovarian tumor.]

    Peng EY*, Shu Y*, Wu Y*, Zeng F, Tan S, Deng Y, Deng Y, Chen H, Zhu L#, Xu H#
    Mol Cancer. 2018;17(1):163

  9. Inherited Coding Variants at the CDKN2A Locus Influence Susceptibility to Acute Lymphoblastic Leukemia in Children.

    Xu H*, Zhang H*, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier Foster JM, Lupo PJ, Neale G, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm JC, Mardis E, Fulton R, Pui CH, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta RG, Schmiegelow K, Loh ML, Relling MV, Yang JJ.
    Nat Commun. 2015 Jun;6:7553

  10. Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss.

    Xu H*, Robinson GW*, Huang J, Lim JY, Zhang H, Bass JK, Broniscer A, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ.
    Nat Genet 2015; 47(3): 263-6. (被Nature杂志评为当月十大研究亮点)

  11. A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.

    Perez-Andreu V*, Roberts KG*, Xu H*, Smith C, Zhang H, Yang W, Harvey RC, Payne.Turner D, Devidas M, Cheng IM, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier Foster JM, Marcucci G, Bloomfield CD, Mrozek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Luger SM, Tallman MS, Dean M, Burchard EG, Torgerson DG, Yue F, Wang Y, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG, Yang JJ.
    Blood 2015; 125(4): 680-6.

  12. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

    Xu H*, Yang W*, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh ML, Yang JJ.
    J Natl Cancer Inst 2013; 105(10): 733-42.

  13. ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.

    Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Hunger SP, Relling MV, Yang JJ.
    J Clin Oncol 2012; 30(7): 751-7.

  14. Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts.

    Xu H*, Wang P*, Fu Y*, Zheng Y, Tang Q, Si L, You J, Zhang Z, Zhu Y, Zhou L, Wei Z, Lin B, Hu L, Kong X.
    Cell Res 2010 Apr; 20(4): 445-57.