Genomic evolution and diverse models of systemic metastases in colorectal cancer

Chen H-N*, Shu Y*, Liao F*, Liao X, Zhang H, Qin Y, Wang Z, Luo M, Liu Q, Xue Z, Cao M, Zhang S, Zhang W-H, Hou Q, Xia X, Luo H, Zhang Y, Yang Lie, Hu J-K, Fu X, Liu B, Hu H, Huang C, Peng Y, Cheng W, Dai L, Yang Li, Zhang W, Dong B, Li Y, Wei Y, Xu H#, Zhou Z-G#.
Gut. 2021; Feb 25

Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer.

Ding Z*, Li Q*, Zhang R*, Xie L, Shu Y, Gao S, Wang P, Su X, Qin Y, Wang Y, Fang J, Zhu Z, Xia X, Wei G, Wang H, Qian H, Guo X, Gao Z, Wang Y, Wei Y, Xu Q#, Xu H#, Yang L#.
Signal Transduct Target Ther. 2021; 6(1): 26

Novel recurrent altered genes in Chinese patients with anaplastic thyroid cancer.

Zhang L*, Ren Z*, Su Z*, Liu Y, Yang T, Cao M, Jiang Y, Tang Y, Chen H, Zhang W, Gong R, Wei T, Peng Y, Liu B, Zhang W, Yang L, Hu Y, Li Z, Zhu J, Xu H#, Shu Y#, Luo H#.
J Clin Endocrinol Metab.  2021;dgab0146


ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia.

Xu H*, Zhao X*, Bhojwani D, E S, Goodings C, Zhang H, Seibel NL, Yang W, Li C, Carroll WL, Evans WE, Yang JJ#.
Clin Cancer Res. 2020; 26(1): 256-264

The Significance of the CLDN18-ARHGAP Fusion Gene in Gastric Cancer: A Systematic Review and Meta-Analysis.

Zhang W*, Zhang S*, Hou Q*, Qin Y, Chen X, Zhou Z, Shu Y#, Xu H#, Hu J#.
Front Oncol.  2020; 10:1214

The Role of ARID5B in Acute Lymphoblastic Leukemia and Beyond.

Wang P*, Deng Y*, Yan X*, Zhu J, Yin Y, Shu Y, Bai D, Zhang S#,Xu H#, Lu X#.
Front Genet.  2020 12;11:598


Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics.

Qian M*, Xu H*, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ.
Blood. 2019 Feb;133(7):724-729

NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis.

Fan X, Yin D, Men R, Xu H#, Yang L.
Front Pharmacol. 2019;10:346

ARL15 overexpression attenuates high glucose-induced impairment of insulin signaling and oxidative stress in human umbilical vein endothelial cells.

Shen J, Liu M, Xu J, Sun B, Xu H, Zhang W.
Life Sci. 2019;220:127-135.

Metabolism-induced tumor activator 1 (MITA1), an Energy Stress-Inducible Long Noncoding RNA, Promotes Hepatocellular Carcinoma Metastasis

Ma M, Xu H, Liu G,Wu J,Li C,Wang X,Zhang S,Xu H,Ju S,Cheng W,Dai L,Wei Y,Tian Y,Fu X
Hepatology. 2019;70(1):215-230


TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ
J Clin Oncol 2018 Feb 20;36(6):591-599

Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.

Zhu Y*, Yin D*, Su Y*, Xia X*, Moriyama T, Nishii R, Liao F, Zhang S, Guo X, Hou Q, Ai Y, Zhou X, Sun S, Zhang D, Zhang Y, Lin C, Deng Y, Lu X, Wang Y, Ma Z, Wang H, Liu B, Yang L, Zhang W, Yang JJ, Shu Y#, Gao J#, Xu H#
Haematologica. 2018;103(7):e293-e295. doi:10.3324/haematol.2018.187658

Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer

Shu Y*, Zhang W*, Hou Q*, Zhao L*, Zhang S, Zhou J, Song X, Zhang Y, Jiang D, Chen X, Wang P, Xia X, Liao F, Yin D, Chen X, Zhou X, Zhang D, Yin S, Yang K, Liu J, Fu L, Zhang L, Wang Y, Zhang J, An Y, Cheng H, Zheng B, Sun H, Zhao Y, Wang Y, Xie D, Ouyang L, Wang P, Zhang W, Qiu M, Fu X, Dai L, He G, Yang H, Cheng W, Yang L, Liu B, Li W, Dong B, Zhou Z, Wei Y, Peng Y#, Xu H#, Hu J#
Nat Commun. 2018;9(1):2447. Published 2018 Jun 30.

Induction and amelioration of methotrexate-Induced gastrointestinal toxicity are related to immune response and gut microbiota.

Zhou B*, Xia X*, Wang P, Chen S, Yu C, Huang R, Zhang R, Wang Y, Lu L, Yuan F, Tian Y, Fan Y, Zhang X, Shu Y, Zhang S, Bai D, Wu L, Xu H#, Yang L#
Ebiomedicine 2018 Jul; 33:122-133.

Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update with New Evidences.

Yan X*, Zhang S*, Deng Y, Wang P, Hou Q, Xu H#
Front Pharmacol. 2018 20;9:1050

Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

Peng EY*, Shu Y*, Wu Y*, Zeng F, Tan S, Deng Y, Deng Y, Chen H, Zhu L#, Xu H#
Mol Cancer. 2018;17(1):163

Insights of Acute Lymphoblastic Leukemia with Development of Genomic Investigation.

Xu H, Shu Y
Methods Mol Biol. 2018;1754:387-413


Rare gene variants in a patient with azathioprine-induced lethal myelosuppression.

Yang X, Xu H, Yang J, Yang L.
Ann Hematol 2017 Aug 22.

Novel gene and network associations found for lymphoblastic leukemia using case-control and family-based studies in multi-ethnic populations.

Nakka P, Archer NP, Xu H, Lupo PJ, Raphael BJ, Yang JJ, Ramachandran S
Cancer Epidemiol Biomarkers Prev. 2017 Jul 27. pii: cebp.0360.2017.

Evidence of genetic factors involved in oral lichen planus pathogenesis.

Wei Z, Hou Q, Xu H, Jiang L, Chen Q.
Oral Dis. 2017 Jul 24. doi: 10.1111/odi.12716.

The novel complex combination of alum, CpG ODN and HH2 as adjuvant in cancer vaccine effectively suppresses tumor growth in vivo.

Tian Y, Li M, Yu C, Zhang R, Zhang X, Huang R, Lu L, Yuan F, Fan Y, Zhou B, Men K, Xu H, Yang L.
Oncotarget 2017 Jul 11;8(28):45951-45964.

The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing.

Ye L, Zhou X, Huang F, Wang W, Qi Y, Xu H, Shu Y, Shen L, Fei X, Xie J, Cao M, Zhou Y, Zhu W, Wang S, Ning G, Wang W.
Nat Commun 2017 Jul 4;8:16129.

Regulatory network of GATA3 in pediatric acute lymphoblastic leukemia.

Hou Q*, Liao F*, Zhang S*, Zhang D*, Zhang Y, Zhou X, Xia X, Ye Y, Yang H, Li Z, Wang L, Wang X, Ma Z, Zhu Y, Ouyang L, Wang Y, Zhang H, Yang L, Xu H#, Shu Y#.
Oncotarget 2017 May; 8(22):36040-36053

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose.

Yin D*, Xia X*, Zhang J*, Zhang S*, Liao F, Zhang G, Zhang Y, Hou Q, Yang X, Wang H, Ma Z, Wang H, Zhu Y, Zhang W, Wang Y, Liu B, Wang L#, Xu H#, and Shu Y#.
Oncotarget. 2017;8(8):13575-13585


Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.

Liao F, Yin D, Zhang Y, Hou Q, Zheng Z, Yang L, Shu Y, Xu H#, Li Y#.
Medicine 2016 May; 95(18): e3542

Inherited Coding Variants at the CDKN2A Locus Influence Susceptibility to Acute Lymphoblastic Leukemia in Children.

Xu H*, Zhang H*, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier Foster JM, Lupo PJ, Neale G, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm JC, Mardis E, Fulton R, Pui CH, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta RG, Schmiegelow K, Loh ML, Relling MV, Yang JJ.
Nat Commun. 2015 Jun;6:7553

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss.

Xu H*, Robinson GW*, Huang J, Lim JY, Zhang H, Bass JK, Broniscer A, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ.
Nat Genet 2015; 47(3): 263-6. (被Nature杂志评为当月十大研究亮点)

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.

Perez-Andreu V*, Roberts KG*, Xu H*, Smith C, Zhang H, Yang W, Harvey RC, Payne.Turner D, Devidas M, Cheng IM, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier Foster JM, Marcucci G, Bloomfield CD, Mrozek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Luger SM, Tallman MS, Dean M, Burchard EG, Torgerson DG, Yue F, Wang Y, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG, Yang JJ.
Blood 2015; 125(4): 680-6.

Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.

Moriyama T, Metzger ML, Wu G, Nishii R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui CH, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ.
Lancet Oncol 2015 Dec; 16(16): 1659-66.

Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations.

Wei Z, Liu Y, Xu H, Tang K, Wu H, Lu L, Wang Z, Chen Z, Xu J, Zhu Y, Hu L, Shang H, Zhao G, Kong X.
Sci Rep 2015 Jun 3; 5:10879.

Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort.

Lin B, Wang Y, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X, Hu G, Hu L.
PLoS One 2014; 9(2): e90215.

De novo structure variations of the Y chromosome in a 47,XXY female with ovarian failure: a case report.

Lin B, Tan F, Xu H, Wang P, Tang Q, Zhu Y, Kong X, Hu L.
Cytogenet Genome Res 2014; 143(4): 221-4.

A new system identification approach to identify genetic variants in sequencing studies for a binary phenotype.

Kang G, Bi W, Zhao Y, Zhang JF, Yang JJ, Xu H, Loh ML, Hunger SP, Relling MV, Pounds S, Cheng C.
Hum Hered 2014; 78(2): 104-16.

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.

Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ.
Nat Genet 2013 Dec; 45(12): 1494-8.

The novel susceptibility variants for childhood acute lymphoblastic leukemia.

Perez-Andreu V, Xu H, Yang JJ.
J Natl Cancer Inst 2013 Oct; 105(19): 1512-3.

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

Xu H*, Yang W*, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh ML, Yang JJ.

J Natl Cancer Inst 2013; 105(10): 733-42.

CEBPE promoter SNPs, caught red handed.

Xu H, Yang JJ.
J Hum Genet 2013; 58(9): 571-2.

ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.

Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Hunger SP, Relling MV, Yang JJ.
J Clin Oncol 2012; 30(7): 751-7.

SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell.

Zhou L, Zhang Z, Zheng Y, Zhu Y, Wei Z, Xu H, Tang Q, Kong X, Hu L.
J Cell Mol Med 2011; 15(4): 783-95.

Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation.

Zhang Z, Zhou L, Hu L, Zhu Y, Xu H, Liu Y, Chen X, Yi X, Kong X, Hurst LD.
Mol Syst Biol 2010 Dec; 6: 442.

Prediction of deleterious non-synonymous SNPs based on protein interaction network and hybrid properties.

Huang T, Wang P, Ye ZQ, Xu H, He Z, Feng KY, Hu L, Cui W, Wang K, Dong X, Xie L, Kong X, Cai YD, Li Y.
PLoS One 2010 Jul 30; 5(7): e11900.

Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts.

Xu H*, Wang P*, Fu Y*, Zheng Y, Tang Q, Si L, You J, Zhang Z, Zhu Y, Zhou L, Wei Z, Lin B, Hu L, Kong X.
Cell Res 2010 Apr; 20(4): 445-57.

Screening of Kozak-motif-located SNPs and analysis of their association with human diseases.

Xu H*, Wang P*, You J*, Zheng Y, Fu Y, Tang Q, Zhou L, Wei Z, Lin B, Shu Y, Zhu Y, Hu L, Kong X.
Biochem Biophys Res Commun 2010 Jan 29; 392(1): 89-94.

Loss-of-function mutations in the PRPS1 gene cause a type of nonsyndromic X-linked sensorineural deafness, DFN2.

Liu X, Han D, Li J, Han B, Ouyang X, Cheng J, Li X, Jin Z, Wang Y, Bitner-Glindzicz M, Kong X, Xu H, Kantardzhieva A, Eavey RD, Seidman CE, Seidman JG, Du LL, Chen ZY, Dai P, Teng M, Yan D, Yuan H.
Am J Hum Genet 2010 Jan 8; 86(1): 65-71.

Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation.

Wang ZQ, Si L, Tang Q, Lin D, Fu Z, Zhang J, Cui B, Zhu Y, Kong X, Deng M, Xia Y, Xu H, Le W, Hu L, Kong X.
Am J Hum Genet 2009 May; 84(5): 672-7.

Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.

Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L.
Lab Invest 2009 Feb; 89(2): 222-30.

Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related.

Lu Y, Yu Y, Zhu Z, Xu H, Ji J, Bu L, Liu B, Jiang H, Lin Y, Kong X, Hu L.
Cancer Lett 2005; 224(2): 329-37.